学术报告201623期

报告题目：Complex DNA self-assembly  and applications

报  告 人：Yonggang Ke (Department of  Biochemical Engineering, Emory University, USA)

报告时间： 6月30日（星期四）下午4:00

报告地点： 南一楼中311室

邀  请  方：“多谱信息处理技术”国家级重点实验室 

Abstract:

    A key challenge in nanotechnology  is to design and fabricate nanostructures/nanodevices. Such systems can serve as  platforms for basic science research (structural biology, molecular biology, for  instance) at nanoscale, and for practical applications. Bottom-up structural DNA  nanotechnology has attracted significant attentions due to its programmability  and its precise control of matter at nanoscale. It has shown increasing  capabilities for basic science research, and for practical  applications.

    Specially, this talk will focus  on recent exciting progress in making massive/complex nanostructure using “DNA  bricks” self-assembly. In 2012, we invented a modular assembly strategy for  constructing complex 3D shapes, up to 8 megadalton in size, using short  synthetic DNA oligos — “DNA bricks”. Here we will discuss this method and how a  quantum leap in term of structure size (up to 500 megadalton) and complexity was  made recently.

In addition, I will explore past and  future works on making biology-inspired devices, such as single-molecule  biosensors and artificial bioreactors, and nanofabrication of functional  nanoscale inorganic materials (especially nanoparticles) using DNA  self-assembly.

Brief Bio:

Yonggang Ke received his PhD in  Chemistry from Arizona State University in 2009. Prior to joining Emory  University in 2014, He was a postdoctoral fellow in Cancer Biology at Harvard  University. Dr. Ke is one of the leading experts in DNA nanotechnology. His  research is highly interdisciplinary which combines Chemistry, Biology, Physics  and Material Science. His research goal is to achieve programmed design and  assembly of biologically inspired nanomaterials and to explore its applications  in biomedical engineering, biomaterials, single-molecule biophysics,  nanoplasmonics, and nanophotonics.

Since 2006, Dr. Ke has published 34  papers, including 3 first-authored articles on Science and 26 papers with impact  factor >10, the SCI other citations reach 2042.