报告题目：DNA Nanotechnology and Application
报 告 人：Thomas LaBean（美国北卡罗莱纳州立大学（North Carolina State University）教授）
报告时间：2016年5月31日（星期二）上午9：30
报告地点：南一楼中311室
邀 请 方：“多谱信息处理技术”国家级重点实验室
Abstract: DNA is a critical biomolecule well-known for its roles in biology and genetics. Moreover, its double-helical structure and the Watson−Crick pairing of its bases make DNA structurally predictable. This predictability enables design and synthesis of artificial DNA nanostructures by suitable programming of the base sequences of DNA strands. Tile-based DNA nanostructures are an integral part of structural DNA nanotechnology. These structures are formed using several short, chemically synthesized DNA strands by programming their base sequences so that they self-assemble into desired constructs. The tiles include, for example, TX tiles with three parallel, coplanar duplexes, 4 × 4 cross-tiles with four arms, and weave-tiles with weave-like architecture. Origami-based structures constitute another category where a long single-stranded DNA scaffold is folded into desired shapes by association with multiple short staple strands. The various DNA nanostructures have been used in a wide variety of different applications in a wide variety of disciplines including electronics, photonics, biomedical engineering, biosensing, therapeutics, and nucleic-acid-based drug delivery.
Biography: Thomas LaBean received his PhD in 1993 from University of Pennsylvania, America . He studied protein design as a postdoctoral fellow at Duke University. He joined the Materials Science and Engineering Faculty in August 2011. His main area of research includes molecular materials, biomolecular engineering, bionano science, molecular self-assembly. His projects involve the design, construction, and testing of self-assembling DNA nanostructures for applications in molecular materials, nanoelectronics, nanophotonics, molecular robotics, and nanomedicine. He has many publications in Science and Nature.
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